The normal range (99% of pollution analyzed) for
platelets is 150,000 to 450,000 cubic millimeter. If the number of platelets is
too low, excessive bleeding can occur, However, if the number of platelets is
too high, blood clots can form thrombosis, which may obstruct blood vessels and
result in such event as a stroke, myocardial infarction, pulmonary embolism, or
blockage of blood v
Vessels to other parts of the body, such as the
extremities of the arms or legs. An abnormality or disease of the platelets is
called thrombocytopathy, which can be a low number of platelets
(thrombocytopenia), a decrease in function of platelets (thrombasthenia), or an
increase in the number of platelets (thrombocytosis). There are disorders that
reduce the number of platelets, such as heparin-induced thrombocytopenia (HIT)
or thrombotic thrombocytopenia purpura (TTP), that typically cause thrombosis,
or clots, instead of bleeding.
Platelets release a multitude of growth factors including
platelet-derived growth factor (PDGF), a potent chemotactic agent, and TGF
beta, which stimulates the deposition of extracellular matrix. Both of this
growth factor has been shown to play a significant role in the repair and
regeneration of connective tissues. Other healing—associated growth factors
produced by platelets include basic fibroblast growth factor, insulin-like
growth factor1, platelet-derived epidermal growth factor, and vascular
endothelial growth factor. Local application of this factor in increased
concentrations through platelet-rich plasma (PRP) has been as an adjunct to
wound healing for several decades.